Table 2.
Symptoms, ocular examination findings, treatments, and outcomes.
| Eye (Case No.) side | 1 (Case 1) OS | 2 (Case 2) OD | 3 (Case 3) OS | 4 (Case 4) OD | 5 (Case 5) OD | 6 (Case 5) OS | 7 (Case 6) OD |
|---|---|---|---|---|---|---|---|
| Baseline VA | HM | CF1M | CF1M | CF4M | CF4M | CF1M | LP |
| Final VA | LP | NLP | 20/200 | 20/63 | 20/50 | 20/200 | LP |
| Presenting symptoms | ↓VA | ↓VA, floater | ↓VA, red eye | ↓VA, floater, red eye | ↓VA | ↓VA, floater | ↓VA, floater, red eye |
| Vitreous culture | Candida spp. | Aspergillus spp. | No growth | No growth | Candida spp. | Candida spp. | Candida spp. |
| Vitreous PCR | Candida spp. | Aspergillus spp. | Candida spp. | Candida spp. | Candida spp. | Candida spp. | Candida spp. |
| SLE findings | AC cells 3+, Flare 1+, hypopyon | AC cells 4+, Flare 2+, fibrin, Hypopyon | AC cells 2+, Flare 1+ | AC cells 1+ | AC cells 1+, Flare 1+ | AC cells 2+, Flare 3+ | AC cells 4+, Flare 2+, fibrin |
| Fundus examination findings | Not visible | Not visible | CWF lesions at posterior pole and vitritis | CWF lesions at posterior pole and vitritis | CWF lesions at posterior pole and vitritis | CWF lesions at posterior pole and vitritis | Not visible |
| Anti-fungal treatment | AmB (IV) VCZ (PO) AmB (IVI, n = 4) |
AmB (IV) VCZ (PO) AmB (IVI, n = 2) |
AmB (IV) VCZ (PO) AmB (IVI, n = 3), PPV, PPV + ERMRa |
AmB (IV) VCZ (PO) AmB (IVI, n = 2) |
AmB (IV) VCZ (PO) AmB (IVI, n = 5) |
AmB (IV) VCZ (PO) AmB (IVI, n = 3), PPVb |
AmB (IV) VCZ (PO) AmB (IVI, n = 3), PPV |
| Follow-up duration | 10 months | Death | 10 months | 8 months | 8 months | 8 months | 7 months |
AC: anterior chamber; AmB: amphotericin B; CFxM: counting fingers at x meter(s); CWF: creamy-white fluffy lesions; ERMR: epiretinal membrane removal; HM: hand motion; IV: intravenous; IVI: intravitreal; LP: light perception; NLP: no light perception; OD: oculus dexter; OS: oculus sinister; PCR: polymerase chain reaction; PO: oral; PPV: pars plana vitrectomy; SLE: slit lamp examination; Spp.: species; VA: visual acuity; VCZ: voriconazole.
Due to incident tractioanl retinal detachment during his hospital stay.
Due to incident exogenous fungal endophthalmitis resulting from intravitreal injections.