Table 2.
Nucleotide mutation rates of SARS-CoV-2 with different nsp14 variants
| Ranking of nsp14 | Substitution in nsp14 | Number of comparison sequences | Substitution rate per year in the whole genome |
|---|---|---|---|
| 1 | – | 25,471 | 19.8 |
| 5 | L177F | 114 | 27.3 |
| 7 | F377L | 51 | 13.0 |
| 11 | S369F | 33 | 26.2 |
| 13 | M501I | 28 | 21.9 |
| 16 | P203L | 24 | 35.9 |
| 17 | L177F/T372I | 26 | 59.8 |
| 18 | P297S | 25 | 17.1 |
The number of mismatched nucleotides in the alignment of the reference sequence with the comparison sequence of each group was counted, and the average value was calculated. hCoV-19/Wuhan/Hu-1/2019 was selected as the reference sequence. Note that the estimated substitution rates were not phylogenetically corrected. —, no mutation was found compared with the hCoV-19/Wuhan/Hu-1/2019 sequence.