Table 3.
Preoperative to postoperative brain volume changes in patients and non-surgical controls
| Surgical patients | Non-surgical controls | B (95% CI) | |||||
|---|---|---|---|---|---|---|---|
| Preoperative | Postoperative | Δ | Preoperative | Postoperative | Δ | ||
| Total brain | 72.1 (2.8) | 71.8 (2.7) | −0.3 (0.9) | 72.0 (3.2) | 72.2 (3.2) | 0.2 (0.8) | −0.50 (−0.83–−0.18)* |
| Gray matter | 39.5 (2.0) | 39.3 (2.0) | −0.2 (0.1) | 39.7 (2.0) | 40.0 (2.0) | 0.2 (0.9) | −0.65 (−1.01–−0.29)** |
| White matter | 32.6 (2.0) | 32.5 (2.0) | −0.1 (0.7) | 32.3 (2.0) | 32.2 (2.2) | 0.0 (0.6) | 0.16 (−0.09–0.41) |
| Cerebrospinal fluid | 27.9 (2.7) | 28.2 (2.7) | 0.3 (0.8) | 28.0 (3.2) | 27.8 (3.2) | −0.2 (0.8) | |
| WMH | 0.17 (0.07–0.36) | 0.18 (0.08–0.39) | 0.02 (0.08) | 0.34 (0.07–0.58) | 0.35 (0.08–0.40) | 0.02 (0.08) | 0.02 (−0.01–0.05) |
Crude volumes are shown as the percentage of the ICV of that time point as mean (standard deviation) or median (interquartile range). B coefficients of the difference in volume change over time between patients and control participants (in % ICV) are shown with a 95% CI and were adjusted for age, sex, study centre, ICV, time between measurements and baseline volume (for example, in gray matter, the B was adjusted for preoperative gray matter volume). Crude cerebrospinal fluid volumes were shown, but not analysed as total brain volume was analysed. WMH: white matter hyperintensities. Number of included patients and control participants per analysis: brain volumes patients: n = 262, control participants: n = 42. White matter hyperintensities patients: n = 246, control participants: n = 44. *P = 0.003. **P < 0.0005.