. Author manuscript; available in PMC: 2023 Feb 16.

Published in final edited form as: J Cardiovasc Aging. 2023 Jan 1;3(1):3. doi: 10.20517/jca.2022.34

Table 1.

Echocardiographic measurements of cardiac size and function in the wild type (WT), Myh6-Mcm^Tam and Myh6-Mcm^Tam:Dsp^F/F mice

	WT	Myh6-Mcm ^Tam	Myh6-Mcm^Tam:Dsp^F/F	One way ANOVA

N	12	8	12	NA
M/F	6/6	4/4	6/6	0.961^*
Age (days)	28.17 ± 0.41	28.50 ± 0.53	28.08 ± 0.29	0.081^#
Body weight (g)	18.40 ± 1.76	15.55 ± 0.92	12.45 ± 1.50	< 0.0001
HR (bpm)	664.90 ± 25.98	673.99 ± 36.93	591.06 ± 40.83	< 0.0001
AWT(mm)	0.39 ± 0.02	0.34 ± 0.02	0.29 ± 0.03	< 0.0001
LVPWT(mm)	0.38 ± 0.02	0.34 ± 0.02	0.28 ± 0.03	< 0.0001
LVEDD (mm)	2.85 ± 0.28	3.01 ± 0.18	3.91 ± 0.49	< 0.0001^#
LVEDDI (mm/g)	0.16 ± 0.03	0.19 ± 0.02	0.32 ± 0.06	< 0.0001^#
LVESD (mm)	1.54 ± 0.15	1.62 ± 0.13	3.21 ± 0.58	< 0.0001^#
LVFS (%)	46.05 ± 1.81	46.10 ± 2.77	18.25 ± 7.12	< 0.0001^#
LV Mass (mg)	20.46 ± 4.21	18.94 ± 1.97	25.24 ± 5.99	0.009^#
LVMI (mg/g)	1.12 ± 0.26	1.22 ± 0.10	2.05 ± 0.55	0.0001^#

Myh6-Mcm: Myosin heavy chain 6-MerCreMer; Dsp: desmoplakin gene; M/F: male/ Female; g: grams; HR: heart rate; bpm: beats per minute; AWST: anterior wall thickness; LVPWT: left ventricular posterior wall thickness; LVEDD: left ventricular end-diastolic diameter; mm: millimeters; LVEDDI: LVEDD indexed to body weight; LVESD: left ventricular end-systolic diameter; LVFS: left ventricular fractional shortening; LVM: left ventricular mass; LVMI: LVM indexed to body weight.

Denotes P-value obtained by chi-square test

Denotes P-value obtained by Kruskal- Wallis test; Data in the WT and Myh6-Mcm ^Tam, in part, include mice reported in the previous studies^[28,35].