Table 3.

Association between pelvic radiation and general health-related patient-reported functional outcomes.

Time	N	Pelvic Radiation, median (quartiles)	No Pelvic Radiation, median (quartiles)	Combined, median (quartiles)	Crude P-valuea	Multivariable adjusted modelb
						Pelvic Radiation vs. No Pelvic Radiation
						Effect estimate (95% CI)	P-value
SF36 physical functioning score
Baseline	564	85 (50, 95)	90 (70, 100)	90 (65, 100)	0.04	n/a
6 month	572	75 (45, 94)	85 (65, 95)	85 (60, 95)	0.003	2.44 (−2.31 to 7.18)	0.31
1 year	550	85 (50, 95)	90 (67, 100)	87 (65, 100)	0.003	2.03 (−2.49 to 6.54)	0.38
3 year	470	75 (45, 90)	85 (60, 95)	85 (55, 95)	0.003	−0.43 (−6.15 to 5.29)	0.88
5 year	415	70 (32, 95)	85 (60, 95)	85 (55, 95)	0.006	−3.74 (−10.92 to 3.43)	0.31
SF36 emotional well being score
Baseline	574	84 (68, 92)	88 (72, 92)	84 (72, 92)	0.76	n/a
6 month	571	84 (75, 92)	84 (71, 92)	84 (72, 92)	0.61	3.01 (0.19 to 5.83)	0.04
1 year	548	84 (68, 92)	84 (72, 92)	84 (72, 92)	0.90	2.30 (−0.31 to 4.91)	0.08
3 year	467	84 (76, 92)	88 (72, 92)	88 (72, 92)	0.71	1.40 (−2.19 to 4.99)	0.44
5 year	414	88 (72, 92)	88 (72, 92)	88 (72, 92)	0.90	2.48 (−1.40 to 6.36)	0.21
SF36 energy and fatigue score
Baseline	574	70 (55, 85)	75 (55, 85)	75 (55, 85)	0.50	n/a
6 month	571	65 (50, 80)	70 (50, 80)	70 (50, 80)	0.25	2.23 (−1.71 to 6.17)	0.27
1 year	548	65 (53, 75)	70 (50, 80)	70 (50, 80)	0.31	1.85 (−1.42 to 5.11)	0.27
3 year	467	70 (55, 80)	70 (55, 80)	70 (55, 80)	0.28	1.80 (−2.11 to 5.70)	0.37
5 year	414	65 (52, 80)	70 (50, 80)	70 (50, 80)	0.48	3.28 (−1.40 to 7.96)	0.17

^aCrude P-values are calculated by Wilcoxon test.

^bAll regression models are adjusted for baseline domain score, time since treatment, biopsy Gleason score, PSA at diagnosis (corrected) and propensity scores.