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. Author manuscript; available in PMC: 2023 Feb 16.
Published in final edited form as: Mol Psychiatry. 2022 Jun 27;27(9):3658–3669. doi: 10.1038/s41380-022-01652-1

Fig. 1. PRISMA flow diagram of systematic searches for studies assessing blood-based biomarkers of antidepressant response to ketamine and esketamine.

Fig. 1

aDatabases used in the searches: Medline (PubMed), Cochrane Library, Embase, PsycInfo, and Web of Science. bHand searching included screening of review articles, grey literature, included papers and manuscripts that cited the included papers. cMeta-analytical calculations were conducted only if there were comparable data on the same blood-based biomarker for at least three studies. If a biomarker was examined in studies with overlapping samples, only the study with largest sample size was included.