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. 2023 Jan 12;120(3):e2213317120. doi: 10.1073/pnas.2213317120

Fig. 5.

Fig. 5.

ALK1 inhibitor ameliorates LPS-induced mortality and experimental metastasis of melanoma cells in mice. (A) Lung colony number in the experimental metastasis models using wild-type mice treated with or without K02288. (n = 4, *P < 0.05 by the unpaired t test). (B) Lung colony number in the experimental metastasis models using Robo4−/− mice treated with or without K02288. (n = 4, N.S., not significant by the unpaired t test). (C) Survival study of LPS-injected wild-type (C57BL/6N) mice treated with or without K02288 (control: n = 17, K02288: n = 18; P = 0.012 by the log-rank test). (D) Survival study using LPS-injected Robo4−/− mice treated with or without K02288 (n = 10; P = 0.523 by the log-rank test). Data are expressed as the mean ± SEM.