Fig. 2.
Effects of blocking TrkB receptor function on the time course of recovery. (A) Experimental schedule. (B–D) Recovery by BV in TrkBF616A mice treated with vehicle or 1NMPP1 infusion. %Change in response magnitude to contralateral deprived-eye (closed → open) (B) and to ipsilateral eye (open → open) (C), and shift in ocular dominance index (D). Sample size for vehicle-treated animals: 12 h (4), 24 h (5), 48 h (5); for 1NMPP1-treated animals: 12 h (4), 24 h (5), 48 h (5). (E–G) Recovery by reverse occlusion in TrkBF616A mice treated with vehicle or 1NMPP1 infusion, presented as %change in the response magnitude to the contralateral deprived eye (closed → open) (E) and to the ipsilateral eye (open → closed) (F); and shift in ocular dominance index (G). *P < 0.05, **P < 0.01 vs. pre-MD baseline, repeated-measure ANOVA followed by multiple comparisons with Bonferroni’s correction. †P < 0.05, ‡P < 0.01 between vehicle- and 1NMPP1-treated groups, one-way ANOVA followed by multiple comparisons with Bonferroni’s correction.