Fig. 6.

Properties which can impact the levels of dissolved oxygen in culture. The different properties can be divided by the scale upon which they act. At the smallest scale, the properties of the cells can change the oxygen properties through varying the rates of depletion in the surrounding media. Medium properties such as the molecular constituents have an impact through the changes in the oxygen solubility. Culture geometry such as the distance to the air-liquid interface and the permeability of vessel walls influence uptake into the medium. The atmosphere that the culture is in also has an impact, with factors such as humidity, pressure and temperature affecting local levels of oxygen concentration.