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[Preprint]. 2024 Sep 21:2023.02.06.527391. Originally published 2023 Feb 7. [Version 2] doi: 10.1101/2023.02.06.527391

Table 2:

Simulation results using the CF-OLS method for correlated putative mediators in scenarios (A7)–(A12). N refers to the sample size. CP refers to coverage probability based on 200 replications. Width refers to half the width of the 95% confidence interval. SE refers to the average asymptotic standard error. SD refers to the empirical standard deviation of replicated estimations. MSE refers to mean squared error. TP refers to the average true positive rate. FP refers to the average false positive rate. The true value of RMed2 is shown in parentheses.

Correlation Structure 1
Correlation Structure 2
Scenario N CP Width SE Bias SD MSE TP FP CP Width SE Bias SD MSE TP FP
(RMed2) % (×10−2) (×10−2) (×10−2) (×10−2) (×10−2) % % % (×10−2) (×10−2) (×10−2) (×10−2) (×10−2) % %
A7 (0) 750 91.5 5.082 2.593 1.317 2.738 0.092 \ 1.3 91.5 4.942 2.522 1.313 2.697 0.090 \ 1.4
1500 93.0 3.489 1.780 0.876 1.946 0.045 \ 1.2 93.5 3.550 1.811 0.720 1.911 0.042 \ 1.3
3000 95.0 2.497 1.274 0.281 1.336 0.019 \ 1.2 98.0 2.494 1.272 0.177 1.146 0.013 \ 1.3
A8 (0.128) 750 95.0 5.667 2.891 0.455 2.732 0.076 100.0 0.0 93.0 5.162 2.634 0.037 2.811 0.079 100.0 0.0
1500 93.5 3.992 2.037 −0.163 2.165 0.047 100.0 0.0 94.5 3.666 1.870 −0.251 1.830 0.034 100.0 0.0
3000 94.5 2.830 1.444 −0.059 1.484 0.022 100.0 0.0 94.5 2.600 1.327 −0.250 1.299 0.017 100.0 0.0
A9 (0.645) 750 96.0 4.074 2.079 −0.090 1.957 0.038 83.5 0.3 95.0 4.218 2.152 −0.164 2.100 0.044 79.0 0.5
1500 96.0 2.878 1.469 −0.147 1.445 0.021 86.0 1.6 95.5 2.991 1.526 −0.028 1.498 0.022 79.2 3.6
3000 93.0 2.049 1.045 −0.404 1.075 0.013 86.9 0.3 95.0 2.120 1.082 −0.221 1.122 0.013 73.5 2.2
A10 (0.315) 750 95.0 5.439 2.775 0.089 2.960 0.087 86.4 2.9 93.5 5.462 2.787 0.304 2.849 0.082 83.5 2.6
1500 95.0 3.869 1.974 −0.196 1.886 0.036 94.5 4.9 93.5 3.871 1.975 0.507 1.995 0.042 67.0 4.8
3000 93.5 2.749 1.403 −0.087 1.462 0.021 95.0 4.3 95.5 2.742 1.399 0.205 1.316 0.018 62.4 3.3
A11 (0.015) 750 92.5 2.015 1.028 0.579 1.131 0.016 96.4 1.6 95.0 1.784 0.910 0.459 0.887 0.010 94.3 1.2
1500 94.5 1.428 0.729 0.334 0.764 0.007 96.8 1.4 95.0 1.278 0.652 0.314 0.706 0.006 94.5 0.3
3000 94.5 0.996 0.508 0.193 0.500 0.003 98.4 0.9 95.0 0.908 0.463 0.218 0.441 0.002 95.0 0.1
A12 (0.003) 750 95.5 1.057 0.539 0.533 0.613 0.007 73.4 3.0 93.5 1.167 0.596 0.542 0.576 0.006 65.2 2.7
1500 93.0 0.690 0.352 0.301 0.374 0.002 99.7 5.4 93.5 0.746 0.381 0.258 0.380 0.002 67.5 4.4
3000 97.5 0.464 0.237 0.140 0.247 0.001 98.6 5.1 96.5 0.492 0.251 0.080 0.261 0.001 60.2 3.4