Table 2. Echocardiography results.
Detailed male and female echocardiogram dataset in mice after 6 weeks of dietary intervention starting from 24 months of age.
| Male Echocardiogram Dataset | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Aged Control | Aged Low Ile | Aged Low AA | Young Control | ||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Sig. vs Control | |
| Weight (g) | 31.57 | 1.38 | 25.86 | 1.22 | 29.40 | 0.81 | 29.20 | 0.80 | Aged Low Ile |
| LV Mass (AW) (mg) | 109.33 | 6.74 | 121.50 | 12.18 | 105.32 | 7.15 | 90.72 | 2.86 | |
| LV Mass/BW (mg) | 3.49 | 0.25 | 4.76 | 0.51 | 3.58 | 0.18 | 3.11 | 0.07 | Aged Low Ile |
| LVID;d (mm) | 4.45 | 0.11 | 4.61 | 0.13 | 4.46 | 0.14 | 4.17 | 0.08 | |
| LVPW;d (mm) | 0.65 | 0.03 | 0.69 | 0.03 | 0.63 | 0.02 | 0.61 | 0.03 | |
| LVID;s (mm) | 3.48 | 0.15 | 3.69 | 0.17 | 3.47 | 0.11 | 3.31 | 0.06 | |
| LVPW;s (mm) | 0.80 | 0.04 | 0.81 | 0.03 | 0.78 | 0.02 | 0.74 | 0.03 | |
| LVAW;d (mm) | 0.66 | 0.02 | 0.66 | 0.03 | 0.64 | 0.03 | 0.64 | 0.02 | |
| LVAW;s (mm) | 0.80 | 0.04 | 0.81 | 0.03 | 0.82 | 0.01 | 0.75 | 0.02 | |
| LV Vol;d (μL) | 90.70 | 5.44 | 98.46 | 6.68 | 91.19 | 7.11 | 77.69 | 3.61 | |
| LV Vol;s (μL) | 50.84 | 5.05 | 59.13 | 6.64 | 50.20 | 4.20 | 44.57 | 1.82 | |
| EF (%) | 44.54 | 2.66 | 40.84 | 3.26 | 44.90 | 1.75 | 42.56 | 0.72 | |
| FS (%) | 22.04 | 1.54 | 20.04 | 1.83 | 22.18 | 1.03 | 20.68 | 0.43 | |
| IVRT (ms) | 19.12 | 1.47 | 17.27 | 1.68 | 20.11 | 1.82 | 17.28 | 1.11 | |
| Stroke Volume (μL) | 39.86 | 1.52 | 39.34 | 2.31 | 40.99 | 3.47 | 33.12 | 1.91 | |
| Heart Rate (bpm) | 489.49 | 21.43 | 476.81 | 21.14 | 517.75 | 26.71 | 480.92 | 24.60 | |
| Cardiac Output (mL/min) | 20.37 | 1.21 | 19.11 | 1.10 | 19.67 | 1.96 | 16.71 | 1.35 | |
| Ao Area (cm) | 1.49 | 0.20 | 2.24 | 0.38 | 1.25 | 0.18 | 1.06 | 0.07 | |
| Ao Mean Vel (mm/s) | 717.31 | 74.51 | 512.96 | 34.50 | 818.39 | 91.26 | 734.91 | 21.09 | Aged Low Ile |
| Ao Mean Grad (mmHg) | 2.17 | 0.47 | 1.08 | 0.14 | 2.78 | 0.60 | 2.17 | 0.13 | |
| Ao Peak Vel (mm/s) | 1277.76 | 112.74 | 892.86 | 64.41 | 1434.55 | 168.96 | 1287.00 | 36.04 | Aged Low Ile |
| Ao Peak Grad (mmHg) | 6.79 | 1.24 | 3.27 | 0.47 | 8.58 | 1.98 | 6.65 | 0.38 | |
| Ejection Time (ms) | 44.12 | 3.15 | 38.47 | 2.68 | 40.35 | 2.63 | 43.69 | 1.87 | |
| Female Echocardiogram Dataset | |||||||||
| Aged Control | Aged Low Ile | Aged Low AA | Young Control | ||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Sig. vs Control | |
| Weight (g) | 28.63 | 1.73 | 23.13 | 0.48 | 28.20 | 0.85 | 24.00 | 1.52 | Aged Low Ile |
| LV Mass (AW) (mg) | 103.13 | 9.38 | 79.45 | 9.35 | 96.27 | 4.32 | 71.29 | 5.47 | Young Control |
| LV Mass/BW (mg) | 3.73 | 0.45 | 3.47 | 0.45 | 3.43 | 0.16 | 2.98 | 0.17 | |
| LVID;d (mm) | 4.42 | 0.09 | 3.92 | 0.19 | 4.39 | 0.11 | 4.11 | 0.11 | Aged Low Ile |
| LVPW;d (mm) | 0.62 | 0.04 | 0.60 | 0.02 | 0.58 | 0.02 | 0.50 | 0.02 | Young Control |
| LVID;s (mm) | 3.47 | 0.08 | 3.08 | 0.21 | 3.45 | 0.10 | 3.31 | 0.17 | |
| LVPW;s (mm) | 0.76 | 0.04 | 0.72 | 0.02 | 0.72 | 0.01 | 0.61 | 0.01 | Young Control |
| LVAW;d (mm) | 0.64 | 0.03 | 0.60 | 0.02 | 0.63 | 0.02 | 0.54 | 0.02 | Young Control |
| LVAW;s (mm) | 0.79 | 0.03 | 0.73 | 0.01 | 0.74 | 0.01 | 0.69 | 0.03 | Young Control |
| LV Vol;d (μL) | 88.96 | 4.07 | 68.42 | 8.30 | 87.88 | 5.10 | 75.21 | 5.05 | |
| LV Vol;s (μL) | 50.07 | 2.80 | 39.32 | 7.00 | 49.91 | 3.38 | 45.20 | 5.77 | |
| EF (%) | 43.88 | 1.05 | 44.68 | 3.34 | 43.44 | 1.56 | 40.68 | 3.87 | |
| FS (%) | 21.59 | 0.59 | 21.97 | 1.90 | 21.34 | 0.86 | 19.73 | 2.12 | |
| IVRT (ms) | 20.72 | 2.32 | 16.63 | 1.72 | 20.50 | 1.60 | 19.33 | 1.88 | |
| Stroke Volume (μL) | 38.90 | 1.64 | 29.10 | 2.00 | 37.97 | 2.40 | 30.01 | 1.83 | Aged Low Ile, Young Control |
| Heart Rate (bpm) | 417.71 | 24.83 | 535.23 | 22.28 | 496.71 | 19.80 | 480.11 | 26.98 | Aged Low Ile, Aged Low AA |
| Cardiac Output (mL/min) | 18.77 | 1.28 | 15.37 | 1.16 | 18.67 | 1.14 | 14.29 | 1.45 | |
| Ao Area (cm) | 1.08 | 0.11 | 1.00 | 0.06 | 1.30 | 0.11 | 1.10 | 0.08 | |
| Ao Mean Vel (mm/s) | 783.91 | 78.03 | 682.80 | 30.99 | 714.48 | 51.60 | 650.10 | 42.24 | |
| Ao Mean Grad (mmHg) | 2.63 | 0.57 | 1.91 | 0.17 | 2.14 | 0.28 | 1.72 | 0.22 | |
| Ao Peak Vel (mm/s) | 1405.10 | 137.05 | 1189.40 | 53.96 | 1256.36 | 102.35 | 1126.18 | 77.47 | |
| Ao Peak Grad (mmHg) | 8.43 | 1.76 | 5.78 | 0.51 | 6.70 | 0.95 | 5.17 | 0.72 | |
| Ejection Time (ms) | 48.47 | 2.56 | 42.01 | 1.60 | 42.64 | 1.56 | 42.11 | 2.17 | |
Statistics - 1-way ANOVA, Dunnett’s Multiple Comparison.