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[Preprint]. 2023 Feb 10:2023.02.09.527936. [Version 1] doi: 10.1101/2023.02.09.527936

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Figure 3. — Metabolism is affected by Frataxin-knockdown in hBMVECs. Basal levels of (A) Oxygen consumption rate (OCR), (B) extracellular acidification rate (ECAR), (C) Total ATP production, (D) ATP produced via mitochondria, and (E) ATP produced by glycolysis are measured in the Agilent Seahorse Mito Stress Test and then normalized to mg protein in the well. (F) The percentage of oxidative phosphorylation and glycolysis. Student’s T-test α =0.05; * p < 0.05, ** p < 0.01, **** p <0.0001. (A). EVEC; n = 47, shFXN; n = 41. (B) EVEC; n = 47, and shFXN; n = 44. (C, D, E and F) EVEC; n = 39, shFXN; n = 38. Representative of 2 biological replicates.