Extended Data Fig. 1: Screening a library of environmental chemicals in developing oligodendrocytes identifies cytotoxic chemicals and modulators of oligodendrocyte generation.

a, Representative heatmaps of one of six primary screening 384-well plates depicting cytotoxic compounds (red), oligodendrocyte inhibitors (blue), and drivers (green). Viability and percent O1+ oligodendrocytes are normalized to vehicle control (DMSO). Thyroid hormone, a known driver of oligodendrocyte generation, is included as a positive control for oligodendrocyte development.

b, Quantification of hits across 6 primary screening plates showing distribution of chemicals identified as cytotoxic (black), drivers (green), and inhibitors (blue).