Table 1.
Study population characteristics
| Total (N=289) | Alive (n=272) | Dead (n=17) | p-value | |
|---|---|---|---|---|
| Recipient Demographics | ||||
| Age at OLT, median (IQR) | 56.6 (48.2, 62.5) | 56.4 (47.5, 62.4) | 59.8 (56.6, 63.9) | 0.06 |
| Male gender | 197 (68.2) | 185 (68.0) | 12 (70.6) | 0.83 |
| Recipient race | ||||
| Caucasian | 177 (61.2) | 168 (61.8) | 9 (52.9) | 0.13 |
| African American | 33 (11.4) | 28 (10.3) | 5 (29.4) | |
| Hispanic | 62 (21.5) | 60 (22.1) | 2 (11.8) | |
| Asian | 8 (2.8) | 8 (2.9) | 0 (0.0) | |
| Other | 9 (3.1) | 8 (2.9) | 1 (5.9) | |
| Recipient race - Black | 33 (11.4) | 28 (10.3) | 5 (29.4) | 0.02 |
| SKLT | 35 (12.1) | 32 (11.8) | 3 (17.6) | 0.47 |
| 28.5 (24.8, 32.6) | 28.6 (24.9, 32.8) | 25.4 (23.0, 32.2) | 0.14 | |
| BMI (kg/m2), median (IQR) | ||||
| Cause of ESLD Code | ||||
| HCV | 80 (27.7) | 69 (25.4) | 11 (64.7) | 0.13 |
| EtOH | 110 (38.1) | 108 (39.7) | 2 (11.8) | |
| NASH/Cryptogenic | 57 (19.7) | 53 (19.5) | 4 (23.5) | |
| Other | 42 | 42 | 15.3 | |
| CRI | 72 (25.0) | 67 (24.7) | 5 (29.4) | 0.66 |
| Diabetes | 97 (33.6) | 94 (34.6) | 3 (17.6) | 0.15 |
| Cardiovascular | 22 (7.6) | 8 (2.9) | 2 (11.8) | 0.05 |
| Pre-transplant Labs, median (IQR) | ||||
| T. bilirubin (mg/dL) | 8.7 (1.5, 22.9) | 8.8 (1.5, 23.1) | 5.3 (2.1, 19.0) | 0.39 |
| INR | 2.0 (1.4, 2.5) | 2.0 (1.4, 2.5) | 2.3 (1.4, 3.2) | 0.61 |
| BUN (mg/dL) | 28.4 (22.0, 42.0) | 28.3 (21.8, 42.2) | 30.3 (24.8, 39.4) | 0.65 |
| Creatinine (mg/dL) | 1.1 (0.8, 1.8) | 1.1 (0.8, 1.8) | 1.1 (1.0, 2.0) | 0.62 |
| Albumin (g/L) | 3.1 (2.7, 3.6) | 3.2 (2.7, 3.7) | 2.9 (2.7, 3.6) | 0.50 |
| Sodium (mEq/L) | 139.0 (136.0, 141.0) | 139.0 (136.0, 141.0) | 141.0 (139.0, 141.0) | 0.23 |
| Pre-transplant Medical Acuity | ||||
| Pressors | 62 (21.5) | 56 (20.6) | 6 (35.3) | 0.15 |
| Vent | 80 (27.7) | 72 (26.5) | 8 (47.1) | 0.07 |
| LOS (days), median (IQR) | 7.0 (1.0, 17.0) | 7.0 (1.0, 17.0) | 7.0 (1.0, 23.0) | 0.83 |
| ICU LOS (days), median (IQR) | 0.0 (0.0, 7.0) | 0.0 (0.0, 7.0) | 6.0 (0.0, 13.0) | 0.30 |
| RRT | 126 (43.6) | 117 (43.0) | 9 (52.9) | 0.42 |
| Pre-transplant Infections (30 days prior to LT) | ||||
| Any Positive Cultures | 104 (36.0) | 98 (36.0) | 6 (35.3) | 0.95 |
| Sepsis | 32 (11.1) | 30 (11.0) | 2 (11.8) | 0.93 |
| Pneumonia | 39 (13.5) | 37 (13.6) | 2 (11.8) | 0.83 |
| UTI | 57 (19.7) | 54 (19.9) | 3 (17.6) | 0.82 |
| Intraabdominal Infection | 21 (7.3) | 17 (6.3) | 4 (23.5) | 0.01 |
IQR, interquartile range; OLT, orthotopic liver transplantation; SKLT, Simultaneous Liver Kidney Transplant; BMI, body mass index; ESLD, end-stage liver disease; HCV, hepatitis C; EtOH, alcohol abuse disorder; NASH, non-alcoholic steatohepatitis; INR, international normalized ratio; BUN, blood urea nitrogen; CRI, chronic renal insufficiency; LOS, length of hospitalization; ICU, intensive care unit; UTI, urinary tract infection.