Table 5.

Cox proportional hazard analysis of pre-transplant risk scores and post-transplant mortality

	Mortality at 6-mo HR (95% CI), p value	Mortality at 1-yr HR (95% CI), p value	Mortality at 3-yr HR (95% CI), p value	Mortality at 5-yr HR (95% CI), p value
MELD	1.01 (0.96, 1.06), p=0.76	1.01 (0.97, 1.05), p=0.58	1.00 (0.98, 1.03), p=0.79	1.01 (0.99, 1.03), p=0.46
MELD-Na	1.01 (0.95, 1.06), p=0.79	1.01 (0.97, 1.05), p=0.58	1.00 (0.98, 1.03), p=0.76	1.01 (0.99, 1.03), p=0.44
MELD 3.0	1.00 (0.95, 1.06), p=0.33	1.01 (0.97, 1.05), p=0.75	1.00 (0.98, 1.03), p=0.83	1.01 (0.98, 1.03), p=0.48
D-MELD	1.00 (1.00, 1.00), p=0.37	1.00 (1.00, 1.00), p=0.39	1.00 (1.00, 1.00), p=0.76	1.00 (1.00, 1.00), p=0.63
MELD-GRAIL	1.02 (0.88, 1.19), p=0.77	1.02 (0.92, 1.15), p=0.67	1.01 (0.94, 1.09), p=0.79	1.02 (0.95, 1.09), p=0.54
MELD-GRAIL-Na	1.02 (0.87, 1.20), p=0.76	1.03 (0.91, 1.15), p=0.66	1.01 (0.93, 1.09), p=0.78	1.02 (0.95, 1.10), p=0.53
UCLA-FRS	1.04 (0.95, 1.15), p=0.48	1.02 (0.95, 1.09), p=0.60	1.01 (0.96, 1.06), p=0.78	1.01 (0.97, 1.06), p=0.52
BAR	1.02 (0.92, 1.14), p=0.68	1.03 (0.95, 1.12), p=0.46	1.02 (0.96, 1.08), p=0.54	1.04 (0.99, 1.09), p=0.15
SOFT	1.01 (0.94, 1.07), p=0.87	1.03 (0.98, 1.07), p=0.23	1.02 (0.99, 1.05), p=0.23	1.02 (1.00, 1.05), p=0.08
P-SOFT	1.01 (0.94, 1.08), p=0.79	1.03 (0.98, 1.08), p=0.23	1.02 (0.99, 1.06), p=0.20	1.03 (1.00, 1.06), p=0.06
LDRI	0.69 (0.09, 5.04), p=0.72	1.09 (0.31, 3.81), p=0.89	1.10 (0.46, 2.66), p=0.83	1.05 (0.48, 2.29), p=0.90
LIFI Score	1.04 (1.03, 1.06), p<0.001	1.05 (1.04, 1.07), p=0.001	1.05 (1.04, 1.06), p<0.001	1.04 (1.03, 1.06), p<0.001
HCV IgG	1.07 (1.01, 1.13), p=0.02	1.06 (1.02, 1.11), p=0.003	1.05 (1.02, 1.07), p=0.001	1.03 (1.00, 1.05), p=0.02
MMP3	1.05 (1.02, 1.07), p=0.001	1.05 (1.03, 1.07, p<0.001	1.05 (1.03, 1.06), p<0.001	1.04 (1.03, 1.06), p<0.001
Fractalkine	1.07 (1.03, 1.11), p<0.001	1.08 (1.05, 1.11), p<0.001	1.07 (1.04, 1.09), p<0.001	1.06 (1.04, 1.09), p<0.001
LIFI Risk Group
LIFI-Low (<46)	(reference)	(reference)	(reference)	(reference)
LIFI-Moderate (47–79)	7.73 (1.42, 42.18) p=0.02	9.24 (2.39, 35.74) p=0.001	4.27 (1.98, 9.22) p<0.001	2.97 (1.54, 5.73) p=0.001
LIFI-High (≥80)	27.6 (4.6, 165.1) p<0.001	50.7 (13.1,196.6) p<0.001	25.6 (10.8, 61.5) p<0.001	17.6 (7.9, 39.1) p<0.001

CI, confidence interval; MELD, Model for End-Stage Liver Disease; GRAIL, GFR assessment in liver disease; UCLA-FRS, University of California Los Angeles Futility Risk Score; BAR, balance of risk; SOFT, survival outcomes following liver transplantation; P-SOFT, predicted survival outcomes following liver transplantation; LDRI, liver donor risk index; LIFI, liver immune frailty index.