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[Preprint]. 2023 Feb 10:rs.3.rs-2367727. [Version 1] doi: 10.21203/rs.3.rs-2367727/v1

Figure 2. Categorizing overall key pathways and genes being regulated in the skin during Spaceflight.

Figure 2

A) An upset plot showing the number of significant (FDR ≤ 0.1) DEGs in Spaceflight versus ground data subsets and the number of overlapping significant DEGs between these data subsets. The colored annotation bar on the left of the plot shows how the original datasets divide into 10 data subsets with various conditions including diet, biological sex and strain. The bar plot on the right of the plot shows the number of significant DEGS in each of the 10 data subsets. The bar plot on the top shows the number of intersecting DEGs between combinations of the data subsets, as indicated by the connected dots within the body of the upset plot. Black connecting lines indicate combinations spanning across multiple missions, and other connecting lines are colored according to the annotation bar, based on their mission. B) A bar plot of the top 10 most significant GOBP pathways found in the union of cross-mission combinations (i.e., DEGs from the black bars in panel A). C) A bar plot of the top 10 most significant GOBP pathways found in the union of intra-MHU-2 combinations (i.e., DEGs from the blue bars in panel A).