Figure 9. Predicted potential countermeasures for mitigating spaceflight response to the skin.

Predicted drug signatures using the key genes across each dataset represented by a hierarchically clustered heat map. A positive (orange) activation state implies key gene expression changes are consistent with mRNA expression changes observed with the indicated drug from curated causal gene expression relationship studies. A negative (blue) activation state implies the key gene expression changes are opposite to mRNA changes observed with the indicated drug.