Table 2.

shows the results for the VBM multivariate linear regression analyses testing the positive relationship between the five ROIs and vo2max.

Neuromodulatory System	side	MNI coordinates			peak T valuea	peak Z scoreb	peak cluster Kec	p value uncorrd	FWEe	FDRf	total number of voxels for p<0.05 with max BF10g
		x	y	Z
vo2 max
Locus Coeruleus**	right	4	−38	−22	3.72	3.39	65	0.000	1.000	1.005	92 (BF10 52.98)
Dorsal Raphe*	/	0	−28	−10	2.77	2.61	5	0.004	1.000	1.005	32 (BF10 9.173)
Median Raphe	right	2	−34	−20	2.01	1.95	6	0.632	1.000	1.005	6 (BF10 2.233)
Ventral Tegmental Area*	right	−2	−24	−18	2.61	2.47	3	0.446	1.000	1.005	30 (BF10 80.35)
Nucleus Basalis of Meynert	left	−16	−8	−8	1.91	1.86	3	0.870	1.000	1.005	3 (BF10 0.150)

The results across the n.41 healthy subjects are covaried for age, gender, total intracranial volume, education and maximal heart rate (maxHR). The table reports the significant clusters of voxels predicting vo2max values for the statistical threshold of p<0.05. Bayesian Factors (BF₁₀) are reported as parameter of strength in brackets. Cluster of voxels surviving p<0.01 are marked with *. Cluster of voxels surviving p<0.001 are marked with **. No clusters survived multiple comparison corrections (FWE).

^a)Peak T value: T value of the most significant cluster of contiguous voxels

^b)Peak Z-score: Z-score of the most significant cluster of contiguous voxels

^c)Peak cluster Ke: number of voxels of the most significant cluster of contiguous voxels

^d)P value uncorrected

^e)FWE = family wise error correction value

^f)FDR = false discovery rate correction value (q)

^g)Total number of voxels outcoming in the ROI including all clusters of contiguous voxels (in brackets are reported Bayes Factors)