Table 4.

reporting the results of the ANCOOVA model treating vo2max as factor divided in 2 levels (above 20, below 20) and Locus Coeruleus average signal intensity as a dependent variable while controlling for age, gender, education, TIV and maxHR. Locus Coeruleus signal intensity significantly differs (Cohens’s d – 1.21) between the 2 groups (P<0.01 Bonferroni corrected).

ANCOVA – Locus Coeruleus signal intensity and VO2Max level
Cases	Sum of Squares	df	Mean Square	F	p
VO2Max Level	0.011	1	0.011	9.847	0.004
gender	0.001	1	0.001	1.123	0.297
age	6.902e-4	1	6.902e-4	0.599	0.444
education	4.150e-6	1	4.150e-6	0.004	0.953
TIV	0.001	1	0.001	1.067	0.309
MaxHR	4.896e-4	1	4.896e-4	0.425	0.519
Residuals	0.039	34	0.001

Bootstrapped Post Hoc Comparisons - Vo2Max level
	99% bca† CI
	Mean Difference	Lower	Upper	SE	bias	t	Cohen’s d	Pbonf
Above 20	0.039	0.014	0.079	0.012	−2.687e-4	3.138	1.212	0.004***

Note. Type III Sum or Squares

^**p < .01

Note. The model is controlled for the effect of age, gender, education, TIV and maxHR.

Note. Mean Difference estimate is based on the median of the bootstrap distribution.

Note. Cohen’s d does not correct for multiple comparisons.

Note. Bootstrapping based on 1000 successful replicates.

Note. Results are averaged over the levels of: gender

^†Bias corrected accelerated