Table 3.

Comparison of individual models and ensembles on holdout dataset (ADNI3).

Model	ROC AUC	Specificity	Sensitivity
Baseline (age + sex + APOE)	0.750 (0.660, 0.831)	0.653 (0.608, 0.696)	0.696 (0.569, 0.807)
PRS	0.730 (0.650, 0.800)	0.667 (0.625, 0.711)	0.712 (0.593, 0.824)
XGBoost	0.818 (0.764, 0.864)	0.729 (0.685, 0.769)	0.817 (0.706, 0.910)
NODEnn	0.754 (0.691, 0.811)	0.559 (0.514, 0.604)	0.816 (0.700, 0.912)
PRS + XBGoost	0.796 (0.729, 0.852)	0.729 (0.687, 0.771)	0.750 (0.627, 0.852)
XGBoost + NODEnn	0.818 (0.765, 0.867)	0.735 (0.693, 0.774)	0.817 (0.706, 0.904)
PRS + NODEnn	0.748 (0.670, 0.816)	0.651 (0.608, 0.694)	0.783 (0.667, 0.883)
PRS + XGBoost + NODEnn	0.797 (0.734, 0.856)	0.751 (0.710, 0.791)	0.750 (0.629, 0.853)