Table 1.
Study populations included, TB case definitions, estimated TB prevalence and estimated TB exposure in controls. Adapted from Schurz et al. TB prevalence and estimated exposure could not be derived for additional registries and studies not part of International TB Host genetics Consortium (N/A = not available).
| Study / Dataset | TB case definition | Population | Cases / Controls | TB prevalence / 100 000 p.a. | Estimated proportion of controls ever exposed to Mtb (±SD) |
|---|---|---|---|---|---|
| Studies from International TB Host genetics Consortium | |||||
| China 1 (unpublished) |
Acid-fast staining and culturing of Mtb from sputum samples | Asian | 483 / 587 | 89 | 0.302 (0.101) |
| China 2 (unpublished) |
Acid-fast staining and culturing of Mtb from sputum samples | Asian | 1290 / 1145 | 89 | 0.302 (0.101) |
| China 3 Qi et al, 2017 |
Acid-fast staining and culturing of Mtb from sputum samples | Asian | 972 / 1537 | 89 | 0.302 (0.101) |
| Thailand - Mahasirimongkol et al 2012 |
Acid-fast staining and culturing of Mtb from sputum samples | Asian | 433 / 295 | 236 | 0.404 (0.112) |
| Japan Mahasirimongkol et al 2012 |
Acid-fast staining and culturing of Mtb from sputum samples. | Asian | 751 / 3199 | 23 | 0.142 (0.125) |
| Russia Curtis et al 2015 |
Acid-fast staining and culturing of Mtb from sputum samples. | European | 5914 / 6022 | 109 | 0.191 (0.093) |
| Estonia (unpublished) |
Biobank TB cases | European | 62 / 2660 | 13 | 0.116 (0.093) |
| Germany (unpublished) |
Not available | European | 586 / 333 | 7.8 | 0.067 (0.081) |
| Gambia WTCCC |
Not available | African | 1316 / 1382 | 126 | 0.280 (0.089) |
| Ghana Thye et al |
Acid-fast staining and culturing of Mtb from sputum samples | African | 1359 / 1952 | 282 | 0.539 (0.198) |
| SAC(A)^ Daya et al |
Acid-fast staining and culturing of Mtb from sputum samples | African | 642 / 91 | 717 | 0.436 (0.127) |
| SAC(M)* Schurz et al |
Acid-fast staining and culturing of Mtb from sputum samples | African | 410 / 405 | 717 | 0.436 (0.127) |
| Additional data sources not included in International TB Host genetics consortium | |||||
| UK Biobank | Self-report of tuberculosis | European | 2,046 / 418,427 | N/A | N/A |
| FinnGen | ICD A15 (Respiratory confirmed tuberculosis) | European | 401 / 321,302 | N/A | N/A |
| Biobank Japan | ICD A15-16 (Respiratory tuberculosis) | Asian | 549 / 211,904 | N/A | N/A |
| Zheng et al | Microbiological and clinical diagnosis | Asian | 833 / 1220 | N/A | N/A |