Table 1.

List of the various clinical phases of epigenetic drugs in the treatment of HCC.

Epigenetic drugs	Preclinical stage	Clinical trials	Ref./clinical trial number	Clinical trial start
Mechanism of action
DNMT inhibitors
Azacitidine	∗		[46]
Decitabine		∗	Phase I/II (NCT01799083)	Dec 2012
CM-272	∗		[55]
Guadecitabine (SGI-110)		∗	Phase II (NCT01752933)	Dec 2012
			Phase I (NCT03257761)	Feb 2018
HDAC inhibitors
Vorinostat		∗	Phase I (NCT01075113)	Aug 2010
Belinostat		∗	Phase I/II (NCT00321594)	May 2006
Panobinostat		∗	Phase I (NCT00873002)	Mar 2009
			Phase 1 (NCT00823290)	Jan 2009
Trichostatin	∗		[61, 62]
Reminostat		∗	Phase II (NCT00943449)	Jul 2009
			Phase I/II (NCT02400788)	Apr 2013

Abbreviations; DNMT : DNA methyltransferases; HDAC: histone deacetylases.