Table 4.
Threshold values for increased odds of experiencing first-time VA in 94 LMNA genotype–positive patients, by 241 ECGs and 441 echocardiographic examinations
| Threshold value | OR before threshold | P-value | OR after threshold | P-value | |
|---|---|---|---|---|---|
| LVEF (%, neg) | 44 | 1.02 | <0.05 | 1.10 | <0.001 |
| GLS (%) | −12.2 | 1.02 | 0.04 | 1.12 | <0.001 |
| LV EDVi (mL/m2) | 77 | 1.02 | 0.04 | 1.08 | <0.001 |
| LV ESVi (mL/m2) | 54 | 1.03 | 0.01 | 1.13 | <0.001 |
| LAVi (mL/m2) | 63 | 1.03 | 0.01 | 1.21 | <0.001 |
| RVD (mm) | 42 | 1.02 | 0.11 | 1.08 | <0.001 |
| TAPSE (mm, neg) | 22 | 1.02 | 0.12 | 1.08 | <0.001 |
| PR interval (ms) | 280 | 1.00 | 0.58 | 1.13 | <0.001 |
| QRS width (ms) | 108 | 1.02 | 0.15 | 1.19 | <0.001 |
Threshold values for reaching point of elevated increase in risk of ventricular arrhythmia, calculated by threshold regression analyses without use of random effects (univariate analysis). LVEF and TAPSE expressed as negative values.
ECG, electrocardiography; GLS, global longitudinal strain; i, indexed value; LAV, left atrial volume; LV EDV, left ventricular end-diastolic volume; LVEF, LV ejection fraction; LV ESV, LV end-systolic volume; OR, odds ratio; RVD, right ventricular diameter basal; TAPSE, tricuspid annular plane systolic excursion; VA, ventricular arrhythmia.