Table 3.

Genetic test results

	Gender	Age at IPG implantation	PR (ms)	Intrinsic QRSa/paced QRS (ms)	Gene variant	Protein Change	NM number	Significance (ACMG criteria)	LVEF at last FU	VP% at last FU
Pt #1	Male	48	–	137/150	TRPM4	p.(Gly844Asp)	017 636.3	US	65%	100%
					c.2531G > A
Pt #2	Female	42	135	88/145	None	–	–	–	63%	8%
Pt #3	Female	19	–	120/160	MYBPC3	p.(Asp358Glu)	000256.3	US	55%	100%
					c.1074T > A
Pt #4	Male	30	150	100/145	None	–	–	–	60%	18%
Pt #5	Female	25	280	90/162	SCN5A	p.(Arg1897Trp)	198056.2	US	55%	80%
					c.5689C > T
					KCNE1	p.(Asp85Asn)	000219.5
					c.253G > A
Pt #6	Male	47	180	99/149	None	–	–	–	58%	7%
Pt #7	Male	44	–	118/162	LMNA	–	–	US	59%	100%
Pt #8	Male	44	148	105/151	None	–	–	–	56%	9%
Pt #9	Male	26	137	96/149	MYBPC3	p.(Asp358Glu)	000256.3	US	61%	9%
					c.1074T > A
Pt #10	Male	44	–	130/175	TRPM4	p.(Gly844Asp)	017636.3	US	62%	100%
					c.2531G > A
Pt #11	Male	49	140	102/158	None	–	–	–	53%	12%
Pt #12	Male	30	245	96/144	PKP2	p.(Lys672ArgfsTer12)	004572.3	Pathogenic	58%	9%
					c.2013delC
Pt #13	Female	33	139	84/153	None	–	–	–	60%	7%
Pt #14	Female	47	150	95/162	GJA5	p.(Arg316His)	005266.6	US	61%	5%
					c.947G > A
Pt #15	Male	45	–	100/152	TRPM4	p.(Gly844Asp)	017636.3	US	60%	100%
					c.2531G > A

US, uncertain significance; IPG, implantable pulse generator; LVEF, left ventricle ejection fraction; VP%, ventricular pacing percentage; FU, follow-up; ACMG, American College of Medical Genetics and Genomics.

Intrinsic QRS intervals refer to measurement performed during the episode of AV block.