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. 2022 Nov 9;25(2):739–747. doi: 10.1093/europace/euac187

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© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Transmural fibrosis profile in atrial fibrillation (AF) patients. (A) Fibrosis fraction as a function of the distance from the epicardium in a representative AF patient. (B) Polarized light images of tissue slices at increasing distance from the epicardium. Scale bar: 500 µm. (C) Transmural fibrosis profile in the AF patient group (n = 8). Different colours and symbols indicate distinct patients. (D) Average transmural fibrosis profile in the AF group. To align patients’ profiles, distance was expressed in relative units (ratio, %).