Table 4.
Recurrence of any atrial arrhythmia at 12 months of AAD after a single procedure
| Persistent AF—Univariate analysis | |||
|---|---|---|---|
| Variable | Recurrence | No recurrence | P-value |
| n = 402 | n = 253 | ||
| Age, years | 67.9 ± 9.8 | 65.5 ± 11.1 | 0.005 |
| Female, n (%) | 146 (36.3%) | 72 (28.5%) | 0.038 |
| Body mass index, kg/m2 | 28.7 ± 5.4 | 28.9 ± 10.9 | 0.777 |
| Hypertension, n (%) | 288 (71.6%) | 168 (66.4%) | 0.156 |
| Diabetes, n (%) | 47 (11.7%) | 31 (12.3%) | 0.829 |
| Vascular disease, n (%) | 121 (30.1%) | 71 (28.1%) | 0.577 |
| Previous stroke or transient ischaemic attack, n (%) | 38 (9.5%) | 17 (6.7%) | 0.219 |
| Left ventricular ejection fraction, % | 52.2 ± 10.6 | 55.6 ± 7.5 | <0.001 |
| CHA2DS2VASC Score | 2.8 ± 1.6 | 2.5 ± 1.7 | 0.05 |
| Additional substrate ablation, n (%) | 325 (80.8%) | 200 (79.1%) | 0.575 |
| vHPSD ablation | 165 (41.0%) | 130 (51.4%) | 0.010 |
| Persistent AF—Multivariate analysis for atrial arrhythmia recurrence | |||
| Variable | Odds ratio | 95% confidence interval | P-value |
| Age | 1.018 | 0.996–1.040 | 0.119 |
| Female | 1.442 | 0.980–2.123 | 0.064 |
| Left ventricular ejection fraction | 1.001 | 0.982–1.020 | 0.936 |
| CHA2DS2VASC Score | 1.019 | 0.880–1.179 | 0.806 |
| vHPSD ablation | 0.608 | 0.434–0.851 | 0.004 |
| Paroxysmal AF—Univariate analysis | |||
| Variable | Recurrence | No recurrence | P-value |
| n = 104 | n = 309 | ||
| Age, years | 64.7 ± 9.2 | 60.9 ± 12.2 | 0.002 |
| Female, n (%) | 56 (53.8%) | 118 (38.2%) | 0.005 |
| Body mass index, kg/m2 | 27.8 ± 4.9 | 28.2 ± 17.4 | 0.795 |
| Hypertension, n (%) | 66 (63.5%) | 166 (53.7%) | 0.083 |
| Diabetes, n (%) | 7 (6.7%) | 24 (7.8%) | 0.729 |
| Vascular disease, n (%) | 29 (27.9%) | 54 (17.5%) | 0.022 |
| Previous stroke or transient ischaemic attack, n (%) | 9 (8.7%) | 23 (7.4%) | 0.677 |
| Left ventricular ejection fraction, % | 58.3 ± 5.9 | 57.8 ± 6.8 | 0.472 |
| CHA2DS2VASC Score | 2.3 ± 1.5 | 1.8 ± 1.7 | 0.015 |
| vHPSD ablation | 53 (51.0%) | 189 (61.2%) | 0.068 |
| Paroxysmal AF—Multivariate analysis for atrial arrhythmia recurrence | |||
| Variable | Odds ratio | 95% confidence interval | P-value |
| Age | 1.024 | 0.995–1.054 | 0.109 |
| Female | 2.060 | 1.243–3.413 | 0.005 |
| Hypertension | 1.337 | 0.744–2.404 | 0.331 |
| Vascular disease | 1.945 | 1.047–3.610 | 0.035 |
| CHA2DS2VASC Score | 0.885 | 0.699–1.122 | 0.314 |
| vHPSD ablation | 0.640 | 0.403–1.017 | 0.059 |
AAD = antiarrhythmic drugs; AF = atrial fibrillation; vHPSD = very high-power short-duration.