Fig. 1. Application of AlphaFold2 complex predictions to a large dataset of human PPIs.
a, Distribution of model confidence score (pDockQ) for predicted structures from two large human protein interaction datasets (hu.MAP and HuRI), compared with confidence metrics from 2,000 random pairs of proteins. The hu.MAP dataset was further subsetted to those that have support from Y2H (‘Y2H’) or crosslink data (‘Crosslinking’), or correspond to pairs with available experimental or homology modeling information (‘Structure’). b, Number of protein interactions with models built from both datasets and those that we consider being of high confidence (‘Predicted’), corresponding to those with pDockQ > 0.5. c, Examples of predicted models (orange and green) overlapped with the corresponding experimental models (gray) and the observed (DockQ) or predicted (pDockQ) quality of the models.