Extended Data Fig. 6. HP1γ signals are not correlated with H3K9me3 at euchromatin regions.

(a) Heatmaps show the TOP1cc-seq signals and H3K9me3 ChIP-seq signals over TOP1cc and HP1γ co-bound regions. Additional 3 kb from the center of the peaks are shown, and the color scale shows the normalized tag numbers. (b) Genomic browsers show TOP1cc CUT&RUN signals, HP1γ and H3K9me3 ChIP-seq signals at selected loci. Enhancer and TOP1cc associated HP1γ are highlighted with light-brown boxes. H3K9me3 associated HP1γ are highlighted with light-purple boxes. (C) Spearman’s correlation analysis on the H3K9me3 ChIP-seq signals and HP1γ ChIP-seq signals at H3K9me3 enriched heterochromatin regions is shown. (D) Spearman’s correlation analysis on the H3K9me3 and HP1γ ChIP-seq signals at TOP1cc and HP1γ co-localized regions is shown. (E) Spearman’s correlation analysis on the TOP1cc CUT&RUN signals and HP1γ ChIP-seq signals at TOP1cc and HP1γ co-locolaized regions is shown.