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. 2023 Feb 6;30(2):148–158. doi: 10.1038/s41594-022-00883-8

Extended Data Fig. 1. CUT&RUN assays disclose TOP1cc signals in LNCAP cells.

Extended Data Fig. 1

(a) Genomic browsers show TOP1cc CUT&RUN signals, AR and Top1 ChIP-seq signals in DHT treated LNCAP cells. IgG and H3K27me3 CUT&RUN signals are serving as the experimental controls for the CUT&RUN assays. Enhancers are highlighted with light-brown boxes. (b) Co-localization analysis of Top1 ChIP-seq signals and TOP1cc CUT&RUN signals in DHT treated LNCAP cells. (c) Heatmaps show Top1 ChIP-seq signals and TOP1cc CUT&RUN signals at TOP1cc-enriched but Top1 ChIP-seq peak undetected regions. Additional 3 kb from the center of the peaks are shown, and the color scale shows the normalized tag numbers. (d) Genomic browsers show TOP1cc CUT&RUN signals, AR and Top1 ChIP-seq signals in DHT treated LNCAP cells. TOP1cc-enriched but Top1 peaks undetected regions are highlighted with light-purple boxes.