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. 2023 Feb 6;30(2):148–158. doi: 10.1038/s41594-022-00883-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (a~d) Genomic browsers show TOP1cc CUT&RUN signals and H3K27Ac ChIP-seq signals at the selected enhancers upon acute E₂ (1 hr) treatment and chronical E₂ (~14 hrs) treatment. Enhancers are highlighted with light-brown boxes. (e) Heatmaps and histogram plots show PRO-seq signals at TOP1cc-enriched MegaTrans enhancers. Additional 3 kb from the center of the peaks are shown, and the color scale shows the normalized tag numbers. (f) Heatmaps and histogram plots show PRO-seq signals at nonTOP1cc enriched MegaTrans enhancers. Additional 3 kb from the center of the peaks are shown.