Table 2.
Comparison of characteristics between the survivors and non-survivors among the patients with idiopathic nonspecific interstitial pneumonia.
| Demographic characteristics | All patients (N = 126) | P value | |
|---|---|---|---|
| Survivors (n = 93) | Non-survivors (n = 33) | ||
| Age, years | 58.8 (± 11.1) | 63.6 (± 10.3) | 0.034 |
| Female sex | 49 (52.7%) | 15 (45.5%) | 0.475 |
| Smoking history | 0.945 | ||
|
Ever smoker Never smoker |
36 (38.7%) 57 (61.3%) |
13 (39.4%) 20 (60.6%) |
|
| Comorbidity | |||
|
Diabetes Hypertension |
23 (24.7%) 14 (15.1%) |
9 (27.3%) 10 (30.4%) |
0.773 0.055 |
| Bronchoalveolar lavage | |||
|
WBC, cells/μL Neutrophil, % Lymphocyte, % Macrophage, % |
180.0 (90.0–300.0) 8.0 (3.0–17.0) 11.0 (4.0–26.0) 69.0 (51.0–83.0) |
140.0 (52.5–217.5) 7.0 (2.0–21.0) 10.0 (5.0–23.0) 70.0 (50.0–87.0) |
0.203 0.845 0.899 0.969 |
| Baseline pulmonary function test | |||
|
FVC, L FVC, % predicted DLCO, mL/min/mmHg DLCO, % predicted |
2.68 (± 0.86) 79.5 (± 18.3) 13.6 (± 4.2) 70.5 (± 18.4) |
2.17 (± 0.56) 67.9 (± 13.1) 10.4 (± 2.9) 58.4 (± 15.2) |
0.002 0.001 < 0.001 0.001 |
| Laboratory findings | |||
| WBC, cells/μL | 7525 (± 2010) | 8633 (± 2266) | 0.010 |
| Monocyte counts, cells/µL | 559.0 (± 188.0) | 612.9 (± 194.7) | 0.164 |
| CRP, mg/dl | 1.0 (± 1.7) | 1.6 (± 2.2) | 0.097 |
| Medical treatments | |||
| Steroids, n | 81 (87.1%) | 32 (97.0%) | 0.109 |
| Immunosuppressants*, n | 19 (20.4%) | 13 (39.4%) | 0.032 |
| Clinical course | |||
| Relapse**, n | 24 (25.8%) | 16 (48.5%) | 0.016 |
| Acute exacerbation, n | 9 (9.7%) | 12 (36.4%) | < 0.001 |
Data are expressed as the mean (± standard deviation), median (interquartile range), or counts (%).
FVC, forced vital capacity; DLCO, diffusing capacity of the lung for carbon monoxide; WBC, white blood cells; CRP, C-reactive protein.
*Medication including azathioprine, mycophenolate mofetil, or tacrolimus.
**Deterioration of clinical course including lung function, symptoms, or radiologic findings and re-prescribed steroids with or without immunosuppressants.