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. 2023 Feb 16;13:2811. doi: 10.1038/s41598-023-28773-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The crude extract of EL001672 and 1′-O-methyl-averantin block the sonic Hedgehog (SHH) signaling pathway. (A,D) Expression of mRNA encoding Gli1, Gli2, SMO, and Bmi-1 by CSC221 cells after treatment with the indicated concentrations of crude extract or 1′-O-methyl-averantin and incubated 48 h. (B–E) Western blot analysis of Gli1, Gli2, SMO, and Bmi-1 protein levels in CSC221 cells treated with indicated concentrations of crude extract and 1′-O-methyl-averantin and incubated 48 h. (C–F) Quantitative analysis of protein expression. 10, 5 and 2.5 µg/ml 1′-O-methyl averantin represent a concentration of 25.90, 12.95 and 6.47 µM, respectively. Data represent the mean ± standard error of the mean, *p < 0.05; **p < 0.01; ***p < 0.001; difference compared with DMSO-treated.