TABLE 1.

The histone methylation site of PRMTs.

PRMTs types	Member	Histone site	Function
Ⅰ	PRMT1	H4R3	Transcription activation Nott et al. (2015); Walker and Burggren (2020)
		H2AR3, R11, R29	Transcription repression Mosammaparast and Shi (2010)
	PRMT2	H3R8	Transcriptional activation Couto et al. (2020)
		H4	Transcription activation Lee and Stallcup (2009)
	PRMT3	H4R3	Transcriptional activation Adli et al. (2015)
	PRMT4/CARM1	H3R2	Transcriptional activation Liu et al. (2020a)
		H3R17, R26	Paternal genome reprogramming Braun et al. (2017)
			Embryo development Xu and Richard (2021)
		H3R42	Transcriptional activation Schneider et al. (2021)
	PRMT6	H2AR3, R29	Transcription repression Mosammaparast and Shi (2010)
		H3R2	Transcriptional activation Diao et al. (2019a)
		H3R42	Transcriptional activation Schneider et al. (2021)
		H4	Unknown
	PRMT8	H4	Unknown
Ⅱ	PRMT5	H2AR3	transcriptional repression Vougiouklakis et al. (2017)
		H3R2	maintain euchromatin Kim et al. (2016)
		H3R8	Transcription repression Hwang et al. (2021)
		H4R3	Transcription repression Hwang et al. (2021)
Ⅲ	PRMT7	H2AR3	Derepress DNA repair Zhao et al. (2019)
		H3R2	maintain euchromatin Kim et al. (2016)
		H4R3	Transcription repression Lim et al. (2013)
		H2BR29, R31, R33	stabilizes nucleosome structure Zhang and Zhuang (2020)
		H4R17	Promote spermatogenesis Lim et al. (2013)
		H4R19	Unknown