TABLE 2.

The role of PRMTs in renal development.

PRMT numbers	Histone modification	Functions and mechanisms	References
CARM1	H3R2me2a	Involved in differentiation of early nephrons and CP, immature kidney and collecting duct by methylation of NICD	Liu et al. (2015), Liu et al. (2020b)
	H3R17me2a	Participate in the differentiation of the cap mesenchyme in its early nephrogenesis collaborating with SIX2	Liu et al. (2015), Liu et al. (2020b)
PRMT5	H3R8me2s	Engage in UB development through E-cadherin together with SIX2	Liu et al. (2015)
PRMT6	H3R2me2a	Co-expressed with Pax2 methylation at early stages of kidney development; Engaged in the regulation of the entire metanephros	Liu et al. (2015), Park et al. (2017)

CP, cap mesenchyme; NICD, notch intracellular domain; PRMT, protein arginine methyltransferase; UB, ureteric bud.