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. 2023 Feb 17;8:69. doi: 10.1038/s41392-023-01341-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 11 — The roles of KDM5-7 on drug resistance. In KDM5 family, KDM5A can promote PI3K/AKT/mTOR pathway through ErbB and induce EMT in combination with KDM5D inhibition, thereby leading to drug resistance. However, KDM5C exerts opposite effects by regulating PTEN and p53, PBIT can inhibit the demethylase activity of KDM5B, which in turn affects the MAPK pathway and cell stemness. Besides, KDM6A and KDM6B can enhance drug resistance by promoting cell stemness and regulating the cell cycle, respectively. Importantly, PHF8 can also upregulate the expression of IL6 and FOXA2 to promote drug resistance