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. 2023 Feb 17;8:69. doi: 10.1038/s41392-023-01341-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — The roles of KDM2 and KDM3 families on drug resistance. KDM2A can promote cell stemness by upregulating the expression of stemness markers Sox2 and Oct4. KDM2B can enhance drug resistance by increasing stem cells and apoptosis at the same time. In addition, KDM3A is able to decrease p53 expression at the transcriptional level and KDM3C can inhibit EMT through the ERK/MAPK signal pathway