Table 1.

Inhibitors against histone demethylases in clinical trials

Drugs	Phase	Trial number	Indications	Status
Tranylcypromine	Phase I/II	NCT02717884	non-M3 Acute Myeloid Leukemia; Myelodysplastic Syndrome	Unknown
	Phase I/II	NCT02261779	Relapsed or Refractory Acute Myeloid Leukemia	Unknown
	Phase I	NCT02273102	Acute Myeloid Leukemia and Myelodysplastic Syndromes	Completed
ORY1001	Phase I	NCT02913443	Small Cell Lung Cancer	Completed
	Phase I	NCT05546580	FLT3-mutated Relapsed or Refractory Acute Myeloid Leukemia	Not yet recruiting
ORY-2001	Phase II	NCT03867253	Alzheimer’s Disease	Completed
	Phase II	NCT04932291	Borderline Personality Disorder	Recruiting
GSK2879552	Phase I	NCT02034123	Relapsed/Refractory Small Cell Lung Carcinoma	Terminated
	Phase I	NCT02177812	Acute Myeloid Leukemia	Terminated
	Phase I/II	NCT02929498	Myelodysplastic Syndrome	Terminated
INCB059872	Phase I	NCT03132324	Sickle Cell Disease	Terminated
	Phase I	NCT03514407	Relapsed Ewing Sarcoma	Terminated
	Phase I/II	NCT02712905	Solid Tumors and Hematologic Malignancy	Terminated
	Phase I/II	NCT02959437	Solid Tumors; Advanced Malignancies; Metastatic Cancer	Terminated
IMG-7289	Phase II	NCT05223920	Thrombocythemia Primary Myelofibrosis	Enrolling by invitation
	Phase I	NCT02842827	Acute Myeloid Leukemia and Myelodysplastic Syndrome	Completed
	Phase I	NCT05597306	Relapsed or Refractory Acute Myeloid Leukemia	Recruiting
	Phase I/II	NCT05191797	Lung Small Cell Carcinoma	Recruiting
	Phase II	NCT04254978	Essential Thrombocythemia	Active, not recruiting
	Phase II	NCT04262141	Essential Thrombocythemia; Polycythemia Vera	Recruiting
	Phase II	NCT03136185	Myelofibrosis	Completed
	Phase II	NCT05569538	Myelofibrosis	Recruiting
	Phase II	NCT04081220	Essential Thrombocythemia	Recruiting
	Phase II	NCT05558696	Polycythemia Vera	Not yet recruiting
TAK-418	Phase I	NCT03228433	Healthy Participants	Completed
	Phase I	NCT04202497	Healthy Volunteers	Terminated
	Phase I	NCT03501069	Healthy Female Participants	Terminated
CC-90011	Phase I	NCT04748848	Acute Myeloid Leukemia	Completed
	Phase I	NCT02875223	Non-Hodgkin’s Lymphomas	Active, not recruiting
	Phase I	NCT03850067	Small Cell Lung Carcinoma	Active, not recruiting
	Phase II	NCT04350463	Advanced Cancers	Active, not recruiting
	Phase I	NCT04628988	Prostatic Neoplasms	Recruiting
SP-2577	Phase I	NCT03895684	Advanced Solid Tumors	Completed
	Phase I	NCT03600649	Relapsed or Refractory Ewing or Ewing-related Sarcomas	Recruiting
	Phase I/II	NCT04734990	Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia	Recruiting
Caffeic acid	Phase III	NCT04648917	Esophagus Cancer	Unknown
	Phase III	NCT03070262	Esophagus Cancer	Unknown
	Phase IV	NCT02556814	Immune Thrombocytopenia	Completed
	Phase III	NCT02351622	Immune Thrombocytopenia	Completed