Table 3.

Predictive factors for subsolid nodule growth by multivariate analysis

Study	number of risk factors	multivariate analysis for growth	OR (95% CI)
Lee et al, 2013 [20]	3	Initial size ≥ 10 mm	6.46 (2.69–15.6)
		Presence of a solid portion	2.69 (1.11–6.95)
		Age ≥ 65 years	2.55 (1.13–5.77)
Eguchi et al, 2014 [21]	2	Smoking history	0.189 (0.056–0.635)
		Mean CT attenuation value	0.985 (0.979–0.990)
Cho et al, 2016 [7]	5	Age ≥ 65 years	5.51 (1.46–20.90)
		History of lung cancer	6.44 (1.73–24.00)
		Initial size ≥ 8 mm	5.74 (1.58–20.92)
		Presence of a solid portion	16.58 (2.04–134.70)
		Air Bronchogram	5.83 (1.41–24.19)
SATO et al, 2017 [10]	2	Past history of lung cancer	5.22 (1.38–23.8)
		GGN size ≥ 10 mm	43.6 (6.01–998)
Shi et al, 2019 [24]	2	Larger 3D maximum diameter	0.896 (0.820–0.948)
		Higher standard deviation	0.810 (0.723–0.883)
Gao et al, 2020 [25]	2	Diameter	1.087 (0.785–1.564)
		Rad-score	5.130 (0.948–37.835)

Note:GGN, ground-glass nodule; OR, odds ratio; 95% CI, 95% confidence interval