Table 3.
Association of clinical factors, target temperature and center with average doses of fentanyl and midazolam equivalents in regression model with and without center, at 12, 24, and 48 h
| Patient characteristics and R-square values | Sedation and analgesia | 12 h | 12 h with center | 24 h | 24 h with center | 48 h | 48 h with center |
|---|---|---|---|---|---|---|---|
| Agea | Fentanyl equivalents | − 0.05 (p = 0.009) | − 0.04 (p = 0.009) | − 0.07 (p = 0.003) | − 0.04 (p = 0.006) | − 0.04 (p = 0.04) | − 0.03 (p = 0.03) |
| Midazolam equivalents | − 0.01 (p = 0.001) | − 0.01 (p < 0.001) | − 0.01 (p < 0.001) | − 0.01 (p < 0.001) | − 0.01 (p < 0.001) | − 0.01 (p < 0.001) | |
| Female sex | Fentanyl equivalents | − 0.04 (p = 0.74) | − 0.12 (p = 0.22) | − 0.03 (p = 0.86) | − 0.08 (p = 0.44) | 0.02 (p = 0.84) | − 0.08 (p = 0.39) |
| Midazolam equivalents | − 0.1 (p < 0.01) | 0.00 (p = 0.80) | − 0.02 (p = 0.14) | 0.00 (p = 0.83) | − 0.01 (p = 0.25) | 0.00 (p = 0.73) | |
| Witnessed arrest | Fentanyl equivalents | − 0.06 (p = 0.71) | 0.01 (p = 0.99) | − 0.01 (p = 0.97) | − 0.03 (p = 0.81) | 0.06 (p = 0.73) | 0.05 (p = 0.69) |
| Midazolam equivalents | 0.00 (p = 0.87) | 0.00 (p = 0.97) | 0.01 (p = 0.51) | 0.00 (p = 0.73) | 0.01 (p = 0.28) | 0.01 (p = 0.41) | |
| Shockable rhythm | Fentanyl equivalents | 0.39 (p = 0.003) | 0.16 (p = 0.11) | 0.49 (p < 0.001) | 0.25 (p = 0.02) | 0.44 (p < 0.001) | 0.24 (p = 0.009) |
| Midazolam equivalents | 0.02 (p = 0.05) | 0.01 (p = 0.34) | 0.03 (p = 0.01) | 0.02 (p = 0.08) | 0.03 (p = 0.007) | 0.02 (p = 0.02) | |
| Time to ROSCb | Fentanyl equivalents | − 0.2 (p = 0.03) | − 0.01 (p = 0.27) | − 0.03 (p = 0.01) | − 0.01 (p = 0.21) | − 0.02 (p = 0.046) | − 0.01 (p = 0.34) |
| Midazolam equivalents | 0.00 (p < 0.001) | 0.00 (p < 0.001) | 0.00 (p < 0.001) | 0.00 (p < 0.001) | 0.00 (p < 0.001) | 0.00 (p = 0.004) | |
| Shock on admission | Fentanyl equivalents | 0.70 (p < 0.001) | 0.35 (p = 0.006) | 0.57 (p = 0.002) | 0.23 (p = 0.10) | 0.58 (p < 0.001) | 0.27 (p = 0.03) |
| Midazolam equivalents | − 0.02 (p = 0.22) | − 0.02 (p = 0.08) | − 0.01 (p = 0.65) | − 0.01 (p = 0.46) | − 0.02 (p = 0.22) | − 0.03 (p = 0.02) | |
| Target temperature 36 °C | Fentanyl equivalents | 0.03 (p = 0.78) | − 0.08 (p = 0.26) | 0.08 (p = 0.45) | 0.00 (p > 0.99) | 0.09 (p = 0.33) | − 0.05 (p = 0.46) |
| Midazolam equivalents | − 0.01 (p = 0.31) | 0.01 (p = 0.17) | − 0.01 (p = 0.59) | − 0.01 (p = 0.43) | 0.00 (p = 0.88) | 0.00 (p = 0.84) | |
| Center effectc | Fentanyl equivalents | p < 0.001 | p < 0.001 | p < 0.001 | |||
| Midazolam equivalents | p < 0.001 | p < 0.001 | p < 0.001 | ||||
| R-square values for the model | Fentanyl equivalents | 0.07 | 0.51 | 0.08 | 0.53 | 0.07 | 0.52 |
| Midazolam equivalents | 0.09 | 0.55 | 0.08 | 0.49 | 0.10 | 0.55 |
significant p-value with the significance level of 0.05 are in bold.
aAge estimate is per 5 year intervals
bTime to ROSC estimate is per 5 min intervals
cCenter effect of global p value using ANOVA testing