Table 2.
Correlations between clinical and MRI-derived variables. Results are expressed as correlation coefficients (r) with 95% bias-corrected and accelerated bootstrap confidence intervals in parentheses (first row) and corresponding p-values (second row)
| EDSS | SDMT | Motor score | |
|---|---|---|---|
| Global MRI metricsa | |||
| T2-LL | 0.200 (0.033, 0.407) 0.03* | − 0.255 (− 0.360, − 0.151) 0.006 | − 0.164 (− 0.324, − 0.029) 0.09 |
| Whole brain volume | − 0.161 (− 0.356, 0.024) 0.09 | 0.177 (0.011, 0.339) 0.06 | 0.245 (0.078, 0.413) 0.009 |
| GM volume | − 0.203 (− 0.370, − 0.027) 0.03* | 0.234 (0.075, 0.386) 0.01 | 0.241 (0.089, 0.381) 0.01 |
| WM volume | − 0.061 (− 0.246, 0.112) 0.52 | 0.057 (− 0.158, 0.257) 0.55 | 0.153 (− 0.016, 0.332) 0.11 |
| NAGM median R1 | − 0.136 (− 0.313, 0.053) 0.15 | 0.076 (− 0.094, 0.250) 0.42 | 0.039 (− 0.132, 0.210) 0.68 |
| NAWM median R1 | − 0,158 (− 0.331, 0.030) 0.10 | 0.167 (− 0.009, 0.338) 0.08 | 0.118 (− 0.042, 0.278) 0.22 |
| NAGM median χ | 0.007 (− 0.187, 0.196) 0.94 | − 0.019 (− 0.201, 0.167) 0.84 | − 0.022 (− 0.224, 0.193) 0.82 |
| NAWM median χ | − 0.084 (− 0.291, 0.140) 0.38 | − 0.030 (− 0.200, 0.141) 0.75 | 0.136 (− 0.049, 0.303) 0.15 |
Significant results are in bold
aCorrelations with clinical scores are corrected for age, sex, and TIV (for volumes only)
*Not significant after FDR correction
EDSS Expanded Disability Status Scale, SDMT Symbol Digit Modalities Test, T2-LL T2 lesion load, GM ray matter, WM = white matter, NAGM normal-appearing gray matter, NAWM normal-appearing white matter