Fig. 1.

Symptoms in patients with large PN. Included patients with active and closed (who had no follow-up visit in 5 years, died and/or transferred or emigrated elsewhere) records at data cut-off; data were available for 31 of 35 paediatric patients and 132 of 172 adult patients with large PN; patients may have reported > 1 symptom and therefore values will not add to 100%. PN plexiform neurofibromas. ^aIncludes compression of the bladder, intestine, trachea, nerve and other. ^bAs per physician’s evaluation. ^cSelf-reported patient burden noted in the medical records included stress due to pain, functional disability, potential future health burden, family and relationship burden and cosmetic burden