Table 1.
GO function and KEGG pathway enrichment results of DEGs regulated by DEMRGs.
| ID | Description | Count | FDR |
|---|---|---|---|
| BP | |||
| GO:0051301 | Cell division | 63 | 1.29E − 07 |
| GO:0016032 | Viral process | 53 | 4.91E − 06 |
| GO:0006260 | DNA replication | 35 | 5.03E − 06 |
| GO:0051437 | Positive regulation of ubiquitin-protein ligase activity involved in the regulation of mitotic cell cycle transition | 22 | 5.45E − 05 |
| GO:0031145 | Anaphase-promoting complex-dependent catabolic process | 22 | 9.07E − 05 |
| GO:0006281 | DNA repair | 41 | 1.75E − 04 |
| GO:0006521 | Regulation of cellular amino acid metabolic process | 17 | 1.75E − 04 |
| GO:0051436 | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 20 | 1.91E − 04 |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 23 | 1.91E − 04 |
| GO:0038061 | NIK/NF-kappaB signaling | 19 | 2.38E − 04 |
|
| |||
| CC | |||
| GO:0005654 | Nucleoplasm | 359 | 2.27E − 34 |
| GO:0005829 | Cytosol | 371 | 3.79E − 23 |
| GO:0005634 | Nucleus | 525 | 1.40E − 20 |
| GO:0005737 | Cytoplasm | 498 | 1.46E − 17 |
| GO:0016020 | Membrane | 247 | 3.51E − 14 |
| GO:0005739 | Mitochondrion | 161 | 4.36E − 11 |
| GO:0005730 | Nucleolus | 106 | 2.07E − 07 |
| GO:0005743 | Mitochondrial inner membrane | 64 | 1.35E − 06 |
| GO:0070062 | Extracellular exosome | 263 | 1.35E − 06 |
| GO:0000502 | Proteasome complex | 19 | 3.52E − 06 |
|
| |||
| MF | |||
| GO:0044822 | Poly(A) RNA binding | 186 | 4.37E − 25 |
| GO:0005524 | ATP binding | 173 | 7.19E − 08 |
| GO:0031625 | Ubiquitin protein ligase binding | 45 | 4.40E − 04 |
| GO:0003723 | RNA binding | 70 | 7.82E − 04 |
| GO:0003684 | Damaged DNA binding | 17 | 0.001372238 |
| GO:0008134 | Transcription factor binding | 42 | 0.002543152 |
| GO:0098641 | Cadherin binding involved in cell-cell adhesion | 42 | 0.003669701 |
| GO:0004812 | Aminoacyl-tRNA ligase activity | 8 | 0.01359803 |
| GO:0003735 | Structural constituent of ribosome | 33 | 0.015456237 |
| GO:0042802 | Identical protein binding | 81 | 0.022626324 |
|
| |||
| KEGG | |||
| hsa03030 | DNA replication | 17 | 1.13E − 06 |
| hsa04110 | Cell cycle | 31 | 3.92E − 06 |
| hsa03050 | Proteasome | 16 | 7.54E − 05 |
| hsa01130 | Biosynthesis of antibiotics | 35 | 0.005013539 |
| hsa00230 | Purine metabolism | 30 | 0.008102754 |
| hsa04141 | Protein processing in the endoplasmic reticulum | 29 | 0.008102754 |
| hsa00900 | Terpenoid backbone biosynthesis | 8 | 0.046861012 |