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. 2023 Feb 17;9:67. doi: 10.1038/s41420-023-01366-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Expression levels of IL-35 in B cells from the peripheral blood from patients with UC and healthy controls were detected by flow cytometry, representative IL-12A⁺ EBI3⁺ expression in CD19⁺ B cells isolated from the healthy control group (n = 14); UC patient group (n = 11). B Dots represent IL-12A⁺ EBI3⁺ cell frequencies in isolated CD19⁺ B cells and total peripheral blood mononuclear cells (PBMCs). C Dots represent IL-12A⁺ EBI3⁺ cell frequencies in total PBMCs. D IL-35 production in the serum from patients with UC and healthy controls were detected by ELISA (healthy control group n = 14; patients with UC group n = 14, two representative independent experiments are presented out of three similar experiments performed). E Expression levels of IL-35 in CD20⁺ B cells from formalin-fixed paraffin-embedded colon tissue sections from six patients with UC and six healthy controls were determined by immunofluorescence staining. B–D Two-tailed unpaired Student’s t-test. Data are shown as mean ±standard error of the mean (SEM) (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).