Table 2.

Minimal inhibition concentration to Ab15151 and its derivative mutant strains.

MIC (µg/mL)	Colistin	Imipenem	Ciprofloxacin	Apramycin	Vancomycin	Tetracycline
Ab15151	1.0–2.0	0.25–0.5	0.13–0.25	4.0–8.0	62.5–125.0	0.5–1.0
ΔpgaB1	1.0–2.0	0.25–0.5	0.13–0.25	4.0–8.0	62.5–125.0	0.5–1.0
ΔpgaB1ΔpgaB2 (ΔΔ)	2.0–16.0*	0.5–1.0	0.13–0.25	4.0–8.0	62.5–125.0	0.5–16.0*
ΔΔ + pgaB1	1.0–4.0	0.5–1.0	0.13–0.25	4.0–8.0	62.5–125.0	0.25–0.5
ΔΔ + pgaB1_S411A	1.0–2.0-	0.5–1.0	0.13–0.25	2.0–4.0	62.5–125.0	0.25–0.5
ΔΔ + pgaB1_S411D	1.0–2.0	0.25–1.0	0.13–0.25	4.0–8.0	62.5–125.0	0.5–1.0
P. aeruginosa**	2.0–4.0	2.0–4.0	0.25–1.0	4.0–8.0	> 500	8.0–16.0

*During 4 times repeat MIC determination, the tolerance to antibiotics was increased.

**MIC to P. aeruginosa ATCC 27853 was performed as standard control.