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. 2023 Feb 16;14:874. doi: 10.1038/s41467-023-36600-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Average percentage of mtDNA-wide C•G to T•A off-target editing in untreated HEK293T cells and HEK293T cells treated with different DdCBEs. The vertical line represents the percentage of mtDNA C•G to T•A editing efficiency in untreated cells. Shown are the mean from n = 2 independent experiments. b Genome-wide circos plots representing the distribution and Detect-seq scores of identified nuclear DNA off-target sites on each chromosome for three different DdCBEs. The number of off-target sites is shown in parentheses. Source data are provided as a Source Data file.