Table 2.
Summary of Findings of studies included for anti-GABABR encephalitis.
| Author/Year | No.Of patients | Mean age | Sex ratio (% males) | Clinical presentation | CSF Abnormality | MRI(abnormality, commonest areas) | EEG abnormality | Cancer rate(%) | Outcome (mRS 0–2) |
|---|---|---|---|---|---|---|---|---|---|
| Kim et al, 2014 | 5 | 63.6 | 3/2 (67) | Confusion and disorientation 100% Psychiatric symptoms 100% Seizures 60% | 80% | 40%, MTL | 5/5 (100) | 4/5 (80) | 5/5 (100) |
| Guan et al, 2015 | 18 | 56.4 | 13/5 (77) | Memory dysfunction 67% Psychiatric symptoms 61% Seizures 94% | NA | 56%, MTL | 12/14 (86) | 6/18 (33) | 11/18 (61) |
| Qiao et al, 2016 | 7 | 51.2 | 6/1 (86) | Memory dysfunction 100% Psychiatric symptoms 100% Seizures 100% | 100% | 57%, Hippocampus, MTL | 7/7 (100) | 4/7 (57) | 3/7 (43) |
| Chen et al,. 2017 | 11 | 51 | 8/3 (72) | Memory dysfunction 90% Psychiatric symptoms 90% Seizures 100% | 100% | 63%, MTL | 7/11 (63) | 3/11 (27) | 7/11 (63) |
| Cui et al, 2018 | 11 | 63 | 7/4 (64) | Memory dysfunction 100% Psychiatric symptoms 46% Seizures 91% | 73% | 36%, Hippocampus, MTL | 10/11 (91) | 5/11 (45) | 8/11 (73) |
| Si et al, 2019 | 5 | 41.2 | 3/2 (60) | Confusion and disorientation 60% Psychiatric symptoms 100% Seizures 80% | 0% | 60%, Hippocampus, MTL | 5/5 (100) | 0/5 (0) | 5/5 (100) |
| Lin et al, 2019 | 28 | 53 | 17/11 (61) | Memory dysfunction 93% Psychiatric symptoms 86% Seizures 96% | NA | 25%, Hippocampus, MTL | 18/24 (75) | 9/28 (32) | 16/28 (57) |
| Zhao et al,.2020 | 12 | 65 | 9/3 (75) | Memory dysfunction 91% Psychiatric symptoms 58% Seizures 91% | 100% | 33%, MTL | 11/12 (91%) | 7/12 (58) | 7/12 (58) |
| Zeng et al, 2020 | 7 | 44.7 | 4/3 (57) | Memory dysfunction 86% Psychiatric symptoms 71% Seizures 100% | 29% | 72%, Hippocampus, MTL | 6/6 (100) | 3/7 (42) | 4/7 (57) |
| Zhang et al, 2020 | 19 | 58.3 | 10/9 (53) | Memory dysfunction 95% Psychiatric symptoms 89% Seizures 90% | NA | 72%, Hippocampus, MTL | 17/19 (89) | 5/19 (26) | 11/19 (58) |
| Zhu et al, 2020 | 14 | 52 | 9/5 (64) | Memory dysfunction 79% Psychiatric symptoms 64% Seizures 100% | NA | 57%, Hippocampus, temporal lobe | 10/14 (71) | 3/14 (21) | NA |
Data are expressed as proportion (%) unless otherwise specified. Age is expressed in years.
anti-GABAB = Anti-gamma-aminobutyric acid B, CSF = cerebrospinal fluid, EEG = electroencephalogram, MRI = magnetic resonance imaging, mRS = modified rankin scores, MTL = medial temporal lobe, NA = not available.