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. 2023 Feb 3;10:1029021. doi: 10.3389/fmed.2023.1029021

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Copyright © 2023 Barker, Hanlon, Marzaioli, Smith, Cunningham, Fletcher, Veale, Fearon and Canavan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated expression of the mTOR pathway in RA synovial tissue. (A) Bar graphs demonstrating normalized gene expression of key components in the mTOR pathway (LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR5, SLC38A9, RRAGC, STRADB, AKT1, and AKT2) via transcriptomic analysis of RNA-Seq (GEO database GSE89408) on synovial tissue biopsies from healthy donors (n = 28) RA patients (n = 151). (B) Clustered heatmap representing DEG involved in metabolism (mTOR pathway) from RASF compared to healthy controls. (C) Known and predicted interactions of dysregulated genes in mTOR pathway. Non-parametric unpaired Mann–Whitney t-test used for comparisons between healthy donors and RA patients. *p < 0.05, ^**p < 0.01, ^****p < 0.0001.