Table 2.
The described effects of curcumin supplementation in poultry animals.
| S. No. | Study | Effective dosage | Animal | Main findings | References |
|---|---|---|---|---|---|
| 1 | Dietary curcumin supplementation protects against heat-stress-impaired growth performance of broilers possibly through a mitochondrial pathway | 100 and 200 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin prevented growth impairment due to heat stress by improving the antioxidant defense system and enhancing the mitochondrial biogenesis | (89) |
| 2 | Effect of various levels of dietary curcumin on meat quality and antioxidant profile of breast muscle in broilers | 50 and 100 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin improved meat quality and muscle oxidant stability with its antioxidative properties | (94) |
| 3 | Curcumin successfully inhibited the computationally identified CYP2A6 enzyme-mediated bioactivation of Aflatoxin B1 in arbor acres broiler | 450 mg/kg | Gallus gallus domesticus (Arbor Acres broiler) | Curcumin inhibited an enzyme associated with AFB1 bioactivation in arbor acres broilers | (107) |
| 4 | Dual role of dietary curcumin through attenuating AFB1-induced oxidative stress and liver injury via modulating liver Phase-I and Phase-II enzymes involved in AFB1 bioactivation and detoxification | 450 mg/kg | Gallus gallus domesticus (Arbor Acres broiler) | Preventive actions of curcumin against AFB1-induced liver injury in broilers | (106) |
| 5 | Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase II detoxifying enzyme systems in broiler chickens | 100 and 200 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin positively modulated antioxidant enzyme GSH and antioxidant activity related pathway | (90) |
| 6 | Evaluation of a solid dispersion of curcumin with polyvinylpyrrolidone and boric acid against Salmonella Enteritidis infection and intestinal permeability in broiler chickens: a pilot study | 0.05 and 0.1% CUR/PVP | Gallus gallus domesticus (Broiler chicken) | Curcumin possessed antimicrobial effects against Salmonella Enteritidis, a bacterial disease of poultry | (92) |
| 7 | Effect of dietary curcumin on the antioxidant status of laying hens under high-temperature conditions | 200 mg/kg | Gallus gallus domesticus (Hen) | Curcumin increased expression levels of antioxidant enzymes in laying hens under heat stress | (91) |
| 8 | Evaluation of cellulosic polymers and curcumin to reduce Aflatoxin B1 toxic effects on performance, biochemical, and immunological parameters of broiler chickens | 0.2 % | Gallus gallus domesticus (Broiler chicken) | Detoxifying effects of curcumin from AFB1 toxins in broilers | (108) |
| 9 | Effects of curcumin on performance, antioxidation, intestinal barrier and mitochondrial function in ducks fed corn contaminated with ochratoxin A | 400 mg/kg | Anas platyrhynchos domesticus (Pekin ducks) | Curcumin reduced enterotoxicity caused by ochratoxin A, a naturally occurring food borne mycotoxin and various other intestinal health parameters | (114) |
| 10 | The effects of different doses of curcumin compound on growth performance, antioxidant status, and gut health of broiler chickens challenged with Eimeria species | 200 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin had effective improvement against Eimeria infection | (48) |
| 11 | Protective effect of curcumin on ochratoxin A–induced liver oxidative injury in duck is mediated by modulating lipid metabolism and the intestinal microbiota | 400 mg/kg | Anas platyrhynchos domesticus (Pekin ducks) | Curcumin modulated the cecum microbiota in ducks and lessened lipid metabolism and OTA-induced injury | (47) |
| 12 | Feed added curcumin with increased solubility on plasma lipoprotein, meat quality, and fat content in broiler chicks | 0.2% | Gallus gallus domesticus (Broiler chicken) | Curcumin reduced total cholesterol and fat content of broiler chicken breast meat | (95) |
| 13 | Effect of curcumin on laying performance, egg quality, endocrine hormones, and immune activity in heat-stressed hens | 150 mg/kg | Gallus gallus domesticus (Hen) | Curcumin supplementation in hen diet improved egg quality and laying performance | (99) |
| 14 | Evaluation of curcumin and copper acetate against Salmonella Typhimurium infection, intestinal permeability, and cecal microbiota composition in broiler chickens | 1:9 ratio of curcumin in polyvinylpyrrolidone | Gallus gallus domesticus (Broiler chicken) | Curcumin displayed its antimicrobial effect and protect broiler chickens from hazardous microbes | (93) |
| 15 | dietary curcumin alleviated acute ileum damage of ducks (Anas platyrhynchos) induced by AFB1 through regulating Nrf2-ARE and NF-κB signaling pathways | 500 mg/kg | Anas platyrhynchos (Duck/Mallard) | Antioxidation and anti-inflammatory activity of curcumin protected the ileum of ducks via activating Nrf2-ARE signaling pathway and inhibiting NF-κB signaling pathway | (110) |
| 16 | Dietary curcumin improves energy metabolism, brain monoamines, carcass traits, muscle oxidative stability and fatty acid profile in heat-stressed broiler chickens | 100 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin increased MUFA and PUFA content in breast and thigh muscles of broilers | (101) |
| 17 | Impact of treating hatching eggs with curcumin after exposure to thermal stress on embryonic development, hatchability, physiological body reactions, and hormonal profiles of Dokki-4 chickens | 250 mg/litter | Gallus gallus domesticus (Dokki-4 chicken) | Curcumin treatments triggered better hatchability traits | (100) |
| 18 | Curcumin supplementation protects broiler chickens against the renal oxidative stress induced by the dietary exposure to low levels of Aflatoxin B1 | 400 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin diminished oxidative stress caused by AFB1 in chicken kidney | (97) |
| 19 | The impact of curcumin on growth performance, growth-related gene expression, oxidative stress, and immunological biomarkers in broiler chickens at different stocking densities | 200 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin increased mRNA expression levels of IGF-1, GHR, MSTN | (88) |
| 20 | Curcumin alleviates LPS-induced intestinal homeostatic imbalance through reshaping gut microbiota structure and regulating group 3 innate lymphoid cells in chickens | 300 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin modulated homeostatis imbalance in gut microbiota through BA-FXR pathway | (112) |
| 21 | The association of curcuma and Scutellaria plant extracts improves laying hen thermal tolerance and egg oxidative stability and quality under heat stress conditions | 1:1 ratio of CUR and SCUT | Gallus gallus domesticus (Hen) | Curcuma supplementation improved oxidative stability and egg shell breaking force | (102) |
| 22 | Curcumin activates the Nrf2 pathway to alleviate AFB1-induced immunosuppression in the spleen of ducklings | 400 mg/kg | Anas platyrhynchos (Ducklings) | Curcumin activated Nrf2 signaling pathway, upregulated the expression of antioxidant enzymes and inhibited NF-κB pathway in ducklings with AFB-1 induced spleen damage | (109) |
| 23 | Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver | 300 mg/kg | Gallus gallus domesticus (Broiler chicken) | Curcumin reduced inflammatory cytokines levels, oxidative stress biomarkers, inflammation genes triggered by AFB1-induced necroptosis through TLR4/RIPK pathway | (111) |
| 24 | Curcumin antagonizes infammation and autophagy induced by arsenic trioxide through immune protection in duck spleen | 400 mg/kg | Anas platyrhynchos (Sanshui white ducks) | Arsenic-induced toxicity was controlled by reduced hyaline degradation and distortion in duck spleen, suppression of various pro-inflammatory cytokines and autophagy-related genes | (113) |