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. 2022 Dec 15;191(2):321–331. doi: 10.1093/toxsci/kfac132

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Characterization of hepatic TCDD-induced gene expression in Ahr^dbd/dbd mice and AHR^dbd protein levels. Hepatic (A) Cyp1a1, (B) Cyp1b1, and (C) Ahr mRNA levels in Ahr^+/+ and Ahr^dbd/dbd after treatment with 100 µg/kg TCDD at the times indicated. D, AHR^wt and AHR^dbd hepatic protein levels and (E) quantification after treatment with DMSO or 100 µg/kg TCDD at the indicated times. Data represent mean ± SEM (N = 3). For A-C, *p ≤ .05 2-way ANOVA compared with DMSO 2 h. For E, *p ≤ .01 2-way ANOVA compared with DMSO 2 h. Abbreviations: DMSO, dimethyl sulfoxide; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin.