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. 2022 Dec 15;191(2):321–331. doi: 10.1093/toxsci/kfac132

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Cloning and characterization of Ahr from Ahr^+/+ and Ahr^dbd/dbd mice. A, Relative Cyp1a1-regulated luciferase activity of COS-1 cells transfected with empty pcDNA3.1, pcDNA3.1-Ahr^wt, and pcDNA3.1-Ahr^dbd plasmids and treated with DMSO or 100 nM TCDD. B, Western blot of AHR^wt and AHR^dbd protein after transfection of COS-1 cells. Data represent mean ± SEM (N = 3). *p < .05 2-way ANOVA compared with DMSO treated empty plasmid. ^#p < .05 2-way ANOVA compared with transfection matched DMSO treated sample. Abbreviations: DMSO, dimethyl sulfoxide; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin.